Population characteristics according to recruitment source

Area of Science:

• Clinical Research
• Biostatistics
• Public Health

Background:

• Recruitment is a critical step in clinical trials.
• Variability in recruitment success across different sources and centers is a known challenge.
• Understanding factors influencing recruitment is essential for trial efficiency.

Purpose of the Study:

• To explore reasons for variability in patient enrollment across recruitment sources and centers.
• To analyze participant characteristics to identify potential predictors of recruitment success.
• To determine if participant data can inform the selection of optimal recruitment sources for clinical trials.

Main Methods:

• Analysis of the proportion of first protocol visits proceeding to patient entry.
• Comparison of recruitment success rates across diverse recruitment sources and clinical centers.
• Statistical analysis of participant characteristics in relation to recruitment outcomes.

Main Results:

• Significant variability was observed in the proportion of participants successfully enrolled from different recruitment sources and centers.
• Certain participant characteristics were found to be associated with differential recruitment success.
• The identified variability suggests that recruitment source selection is not uniform.

Conclusions:

• The observed variability in clinical trial recruitment highlights the need for strategic source selection.
• Participant characteristics offer potential insights for optimizing recruitment strategies.
• Leveraging these insights can improve the efficiency and effectiveness of clinical trial recruitment.