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Population characteristics according to recruitment source

D B Hunninghake, J Knoke, M LaDouceur

    Circulation
    |December 1, 1982
    PubMed
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    Clinical trial recruitment shows significant variability between sources and centers. Analyzing participant characteristics can help optimize the selection of effective recruitment sources for future studies.

    Area of Science:

    • Clinical Research
    • Biostatistics
    • Public Health

    Background:

    • Recruitment is a critical step in clinical trials.
    • Variability in recruitment success across different sources and centers is a known challenge.
    • Understanding factors influencing recruitment is essential for trial efficiency.

    Purpose of the Study:

    • To explore reasons for variability in patient enrollment across recruitment sources and centers.
    • To analyze participant characteristics to identify potential predictors of recruitment success.
    • To determine if participant data can inform the selection of optimal recruitment sources for clinical trials.

    Main Methods:

    • Analysis of the proportion of first protocol visits proceeding to patient entry.
    • Comparison of recruitment success rates across diverse recruitment sources and clinical centers.

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  • Statistical analysis of participant characteristics in relation to recruitment outcomes.

    • Main Results:

    • Significant variability was observed in the proportion of participants successfully enrolled from different recruitment sources and centers.
    • Certain participant characteristics were found to be associated with differential recruitment success.
    • The identified variability suggests that recruitment source selection is not uniform.

    Conclusions:

    • The observed variability in clinical trial recruitment highlights the need for strategic source selection.
    • Participant characteristics offer potential insights for optimizing recruitment strategies.
    • Leveraging these insights can improve the efficiency and effectiveness of clinical trial recruitment.