Sulphonamides in buffaloes: effect on certain blood constituents and serum enzymes

1. Three groups of four clinically healthy buffaloes were injected with sulphadiazine, or sulphadimidine, or sulphathiazole in a single dose of 100 mg/kg body weight. 2. Changes in the serum enzyme activities (SGOT, SGPT and alkaline phosphatase) observed with the tested sulphonamides were insignificant, except for increases in SGOT level 6 h after sulphathiazole injection, and in GOT/GPT ratio 30 min and 24 h after sulphadimidine injection. 3. The creatinine level was not affected in sulphonamide-injected animals. All blood samples collected 15 min to 24 h after sulphathiazole injection showed marked increase in glucose and urea levels. Concerning the other two sulphonamides, no significant change was observed in these parameters except for an increased glucose level 24 h after sulphadiazine injection.