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Ovine placental cortisol production

J F Clapp, N C Thabault, C A Hubel

    Endocrinology
    |November 1, 1982
    PubMed
    Summary

    The ovine placenta synthesizes cortisol, a key hormone, during pregnancy. This study confirms placental cortisol production in vivo and in vitro using radioimmunoassay techniques.

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    Area of Science:

    • Reproductive biology
    • Endocrinology
    • Perinatal medicine

    Background:

    • Cortisol is a vital hormone during pregnancy.
    • The ovine placenta's role in cortisol production requires further elucidation.
    • Understanding placental hormone synthesis is crucial for fetal development.

    Purpose of the Study:

    • To investigate cortisol levels in ovine placental vasculature.
    • To determine if the ovine placenta synthesizes cortisol in vivo and in vitro.

    Main Methods:

    • Radioimmunoassay was used to measure cortisol levels.
    • Blood samples were collected from uterine and umbilical vessels in pregnant ewes.
    • Dispersed placental cells were used for in vitro synthesis studies.

    Main Results:

    • Cortisol levels were significantly higher in uterine and umbilical veins compared to arteries.
    • In vitro studies demonstrated placental synthesis of 11-deoxycortisol and cortisol from 17 alpha-hydroxyprogesterone.
    • 67 out of 73 sample sets showed higher venous cortisol levels.

    Conclusions:

    • The ovine placenta actively synthesizes cortisol.
    • These findings provide strong evidence for in vivo and in vitro placental cortisol production.
    • This highlights the placenta's significant endocrine function during late pregnancy.

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