[Effect of cholestyramine on lipoprotein metabolism in rat blood]

The effect of cholestyramine on lipoprotein metabolism in the rat blood has been explored. Administration of cholestyramine changed both the concentration and the ratio of lipid components in all the classes of lipoproteins. Despite the fact that the activity of postheparin lipoprotein lipase was unchanged upon cholestyramine action, almost double rise in the activity of LChAT and an increase in the specific radioactivity of LDL attests to the intensification of VLDL metabolism. Therefore, the increased biosynthesis of VLDL by the liver is the main reason for the development of hypertriglyceridemia upon the action of cholestyramine.