Pharmacokinetics of fructose-1, 6-diphosphate in the rat

The pharmacokinetics of fructose-1, 6-diphosphate administered to the rat by intravenous injection was studied. Labelled fructose-1, 6-diphosphate was measured in blood, where it reaches the highest amount 10 min after administration, and in different organs. Residual radioactivity was measured in organs 20 min after administration, the highest values being found in the kidney and the lowest in the brain. The hydrolytic activity of the various organs toward fructose-1, 6-diphosphate was measured in organ extracts and was found to be maximal in the kidney and minimal in the brain.