[Analysis of the role of endogenous opioid peptides in experimental hypertension]

In Wistar rats, spontaneously hypertensive rats (SHR) and in rats with one-kidney Goldblatt hypertension, naloxone (0.1 and 1.0 mg/kg) evoked the 10 mm Hg increase of blood pressure in the two groups of hypertensive rats, did not change sensitivity of their baroreceptor reflex but facilitated the reflex in normotensive rats. A possible role of endogenous peptides in blood pressure control is discussed in relation to their ability to stimulate mu- and delta-opiate receptors.