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Central effect of ergometrine on gastric acid secretion in rats
General Pharmacology
|January 1, 1982
Abstract:
1. The ergot alkaloid ergometrine administered by rapid intravenous injection (0.5--4 mg/kg) or by continuous intravenous infusion (0.5--2 mg/kg per hr) stimulated gastric acid secretion in rats and its effect was antagonized by cimetidine (2 mg/kg per hr). 2. The gastric stimulant action can be elicited also by intracerebro-ventricular administration (25--100 micrograms) suggesting a central mechanism of action of ergometrine.