[Wegener's granulomatosis causing diabetes insipidus]

Very few cases of Wegener's granulomatosis which were associated with diabetes insipidus have hitherto been described. Our patient was a young man with severe (also histological) changes in the nose and paranasal sinuses. Typical pulmonal involvement developed. The hypothalamus seemed not to be affected; hyperprolactinemia, as described by other authors, did not exist. A computerized tomography was normal with regard to the hypothalamus. Typically the disease responded well to cyclophosphamide. An affection of the anterior lobe of the hypophysis was not demonstrable; likewise the kidneys were unaffected.