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Related Experiment Videos

Disseminated Cryptococcus treated with transfer factor

P A Gross, C Patel, L E Spitler

    JAMA
    |November 24, 1978
    PubMed
    Summary
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    Amphotericin B for cryptococcal meningitis caused heart and lung toxicity. Transfer factor therapy successfully treated subsequent skin abscesses, leading to a full recovery.

    Area of Science:

    • Infectious Diseases
    • Pulmonology
    • Cardiology

    Background:

    • Cryptococcal meningitis is a serious fungal infection often treated with amphotericin B.
    • Amphotericin B, while effective, carries a risk of significant cardiotoxicity and pulmonary side effects.
    • This case highlights a complex patient response to standard treatment protocols.

    Observation:

    • A patient undergoing amphotericin B therapy for cryptococcal meningitis developed cardiac toxic reactions and left lower lobe pulmonary consolidation.
    • Following surgical resection of the affected lung lobe, the patient presented with multiple subcutaneous cryptococcal abscesses.
    • Intravenous flucytosine therapy proved ineffective in eradicating these disseminated lesions.

    Findings:

    • Surgical intervention for pulmonary complications of cryptococcal meningitis led to the emergence of disseminated cryptococcal abscesses.

    Related Experiment Videos

  • Standard antifungal therapy (flucytosine) failed to resolve the subcutaneous lesions.
  • A combination of transfer factor therapy and surgical drainage successfully eliminated the skin abscesses.

    • Implications:

    • Transfer factor therapy shows promise in managing refractory or disseminated cryptococcal infections, particularly cutaneous manifestations.
    • This case underscores the importance of monitoring for and managing potential adverse effects of amphotericin B therapy.
    • Multidisciplinary approaches involving infectious disease specialists, surgeons, and immunologists may be crucial for complex fungal infections.