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Optic nerve blood flow and its regulation

J M Weinstein, D Funsch, R B Page

    Investigative Ophthalmology & Visual Science
    |November 1, 1982
    PubMed
    Summary

    Intracranial optic nerve blood flow in sheep mirrors cerebral white matter. It remains stable during changes in blood pressure, indicating autoregulation.

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    Area of Science:

    • Ophthalmology
    • Neuroscience
    • Physiology

    Background:

    • The intracranial optic nerve is crucial for vision, yet its blood supply dynamics are not fully understood.
    • Cerebral white matter blood flow is well-characterized, providing a comparative basis for other brain tissues.

    Purpose of the Study:

    • To measure and characterize the blood flow within the intracranial optic nerve of adult sheep.
    • To investigate the autoregulation of optic nerve blood flow in response to changes in carbon dioxide levels (PaCO2) and arterial blood pressure.

    Main Methods:

    • Utilized the radiolabeled microsphere technique for precise regional blood flow measurement.
    • Studied 30 adult sheep under controlled anesthesia.
    • Assessed blood flow under basal conditions, during induced hypercarbia and hypocarbia, and with arterial blood pressure alterations.

    Main Results:

    • Basal blood flow in the intracranial optic nerve was measured at 14 +/- 1 ml/100 gm/min, similar to cerebral white matter.
    • Responses to hypercarbia and hypocarbia mirrored those observed in other cerebral white matter.
    • Intracranial optic nerve blood flow demonstrated autoregulation, remaining constant despite changes in arterial blood pressure within physiological limits.

    Conclusions:

    • The intracranial optic nerve exhibits blood flow characteristics comparable to cerebral white matter.
    • Optic nerve blood flow is actively regulated, maintaining stability across a range of arterial blood pressures, consistent with cerebral autoregulation.

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