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[Study on tobramycin concentration in bone marrow (author's transl)]
The Japanese Journal of Antibiotics
|September 1, 1978
Abstract:
Tobramycin (TOB) concentration in the bone marrow of tibia was examined 1, 2, 3 and 4 hours after intramuscular injection of 60 mg: TOB concentration in the bone marrow of tibia 1 hour after injection was 2.8 +/- 0.578 microgram/ml. Ratio to serum was 87.5%. TOB concentration in the bone marrow of tibia 2 hours after injection was 1.6 +/- 0.480 microgram/ml. Ratio to serum was 94.1%. TOB concentration in the bone marrow of tibia 3 hours after injection was 1.1 +/- 0.337 microgram/ml. Ratio to serum was 84.6%. TOB concentration in the bone marrow of tibia 4 hours after injection was 0.8 +/- 0.372 microgram/ml. Ratio to serum was 80.0%. Penetration capacity of TOB into the bone marrow of tibia was excellent.