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Related Experiment Videos

Death in pemphigus

A R Ahmed, R Moy

    Journal of the American Academy of Dermatology
    |August 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Pemphigus, a fatal skin disease, often leads to death from infection, particularly Staphylococcus aureus septicemia originating from skin lesions. Long-term corticosteroid use masked inflammation, contributing significantly to mortality.

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    Area of Science:

    • Dermatology
    • Pathology
    • Immunology

    Background:

    • Pemphigus is a severe, often fatal, autoimmune blistering skin disease.
    • Understanding mortality factors in pemphigus is crucial for patient management.

    Purpose of the Study:

    • To investigate the causes of death and contributing factors in patients with pemphigus.
    • To analyze clinical and autopsy data from deceased pemphigus patients.

    Main Methods:

    • Retrospective review of patient records and autopsy findings.
    • Histological and immunofluorescent confirmation of pemphigus diagnosis.
    • Analysis of infection sources, common pathogens, and serum protein levels.

    Main Results:

    • Infection was the primary cause of death, with septicemia (Staphylococcus aureus) in 9 of 13 cases.

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  • Pneumonia was prevalent, and skin lesions were common infection sources.
  • Low serum protein and albumin levels were observed in most patients.
  • Corticosteroid therapy masked inflammatory signs, complicating diagnosis and treatment.

    • Conclusions:

    • Infection, especially Staphylococcus aureus septicemia, is a major cause of mortality in pemphigus.
    • Long-term high-dose corticosteroid therapy is a significant contributing factor to pemphigus mortality.
    • Judicious use of corticosteroids is recommended to mitigate risks.