Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Androgen and oestrogen dynamics in hyperthyroidism

E C Ridgway, F Maloof, C Longcope

    The Journal of Endocrinology
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

    Hormones and behavior·2013
    Same author

    Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al.

    Frontiers in neuroendocrinology·2013
    Same author

    Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

    Andrology·2013
    Same author

    Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

    Hormone research in paediatrics·2013
    Same author

    Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

    European journal of endocrinology·2013
    Same author

    Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

    Endocrinology·2013
    Same journal

    Chronic hyperinsulinemia accelerates adipose senescence via mitochondrial dysfunction and cGAS-STING signalling.

    The Journal of endocrinology·2026
    Same journal

    Probiotic Lactobacillus reuteri KUB-AC5 provides cardioprotection via mitigating cardiac mitochondrial dysfunction in obese rats.

    The Journal of endocrinology·2026
    Same journal

    Relationship between hypothalamic astrocytes and gonadotropin-releasing hormone neurons in the female plains vizcacha.

    The Journal of endocrinology·2026
    Same journal

    Passive exercise failed to reverse OVX-induced bone microstructural degeneration to the extent achieved by HRT.

    The Journal of endocrinology·2026
    Same journal

    Downregulation of SLC32A1 mediates the PAI-1 pathway in alleviating hepatic stellate cell activation and liver fibrosis.

    The Journal of endocrinology·2026
    Same journal

    Triiodothyronine-driven pro-inflammatory responses of dendritic cells are restrained by sphingolipid signaling.

    The Journal of endocrinology·2026
    See all related articles

    Hyperthyroidism alters sex hormone metabolism, decreasing clearance rates for testosterone and oestradiol. Increased sex hormone-binding globulin in hyperthyroidism affects androgen and oestrogen dynamics.

    Area of Science:

    • Endocrinology
    • Metabolic Research

    Background:

    • Hyperthyroidism is associated with significant metabolic changes.
    • Sex hormone dynamics can be influenced by thyroid status.

    Purpose of the Study:

    • To investigate the impact of hyperthyroidism on the metabolism and production of androgens and estrogens.
    • To elucidate the specific alterations in metabolic clearance rates and conversion ratios of key sex hormones.

    Main Methods:

    • Constant infusions of radiolabeled testosterone, androstenedione, oestradiol, and oestrone were administered.
    • Measurement of metabolic clearance rates, conversion ratios, and production rates of these hormones.

    Main Results:

    • Decreased metabolic clearance rates for testosterone and oestradiol; normal for androstenedione and oestrone.

    Related Experiment Videos

  • Altered conversion ratios: decreased testosterone to androstenedione/dihydrotestosterone (DHT), increased androstenedione to testosterone/DHT.
  • Elevated production rates for androstenedione and oestrone in some subjects.
  • Changes potentially linked to increased sex hormone-binding globulin (SHBG) levels.

    • Conclusions:

    • Hyperthyroidism significantly impacts sex hormone metabolism, particularly affecting testosterone and oestradiol clearance.
    • Increased SHBG levels in hyperthyroidism may explain observed alterations in androgen metabolism.
    • Further research is warranted to fully understand the clinical implications of these hormonal shifts in hyperthyroid patients.