Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain weights in alcoholics

C G Harper, P C Blumbergs

    Journal of Neurology, Neurosurgery, and Psychiatry
    |September 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Alcoholism significantly reduces male brain weight, even without nutritional deficiencies like Wernicke's encephalopathy. This study indicates alcohol itself is a primary factor in alcohol-related brain damage and weight reduction.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Retinal photoreceptor damage produced in guinea pigs by tunicamycin.

    Australian veterinary journal·2020
    Same author

    Characterization of an 'Amyloid Only' Transgenic (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) Mouse Model of Alzheimer's Disease.

    Journal of comparative pathology·2017
    Same author

    Temporal Sequence of Autolysis in the Cerebellar Cortex of the Mouse.

    Journal of comparative pathology·2016
    Same author

    Concentrations of transferrin and carbohydrate-deficient transferrin in postmortem human brain from alcoholics.

    Addiction biology·2016
    Same author

    Biomechanical studies in an ovine model of non-accidental head injury.

    Journal of biomechanics·2014
    Same author

    Changes in substance P and NK1 receptor immunohistochemistry following human spinal cord injury.

    Spinal cord·2013
    Same journal

    Diagnostic accuracy of a two-cut-off approach using the FAQ/MMSE ratio and FAQ for clinical preselection of patients for anti-amyloid therapy.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Cancer risk and mortality in patients with multiple sclerosis in Finland: a retrospective population-based cohort study.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Visuospatial working memory in Huntington's disease: behavioural and structural brain correlates.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Characteristics and outcomes in electric scooter-related traumatic brain injuries in Helsinki.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Chronological ageing and ovarian reserve in MS: insights from anti-Müllerian hormone and disability progression.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Durable fluoropolymer drug-eluting stent versus bare-metal stent for the prevention of intracranial in-stent restenosis.

    Journal of neurology, neurosurgery, and psychiatry·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Toxicology
    • Public Health

    Background:

    • Alcoholism is a prevalent condition associated with various health issues.
    • Brain damage in alcoholics is often attributed to nutritional deficiencies, such as Wernicke's encephalopathy.

    Purpose of the Study:

    • To investigate the impact of alcoholism on brain weight in a cohort of male alcoholics.
    • To differentiate the effects of alcohol consumption from nutritional deficiencies on brain weight.

    Main Methods:

    • Analysis of brain weights from 168 male alcoholics.
    • Comparison of alcoholic brain weights to a normal population.
    • Identification of subgroups based on the presence or absence of nutritional brain damage (Wernicke's encephalopathy).

    Related Experiment Videos

    Main Results:

    • Male alcoholics exhibited significantly lower mean brain weights compared to the normal population (p < 0.001).
    • Both alcoholics with and without diagnosed Wernicke's encephalopathy showed reduced brain weights.
    • Brain weight reduction was observed even in cases where nutritional damage was unlikely.

    Conclusions:

    • Alcohol consumption is a significant factor contributing to reduced brain weight in alcoholics.
    • The detrimental effect of alcohol on brain weight may be more pronounced than that of nutritional deficiencies alone.
    • Alcohol-induced neurotoxicity plays a crucial role in brain structure alterations observed in alcoholism.