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Long-term axonal apposition in rat sciatic nerve neuroma

J J Bernstein, D Pagnanelli

    Journal of Neurosurgery
    |November 1, 1982
    PubMed
    Summary
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    Electrophysiological cross-talk in rat sciatic nerve neuromas may stem from anatomical changes. Unmyelinated nerve fibers within Schwann cell processes can form direct contact, potentially explaining nerve signal interference and pain.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Surgical Pathology

    Background:

    • Long-term electrophysiological cross-talk between nerve fibers is known to occur in rat sciatic nerve neuromas.
    • The underlying anatomical basis for this phenomenon requires elucidation.

    Purpose of the Study:

    • To investigate the ultrastructural changes in rat sciatic nerve neuromas.
    • To establish an anatomical basis for physiological cross-talk between nerve fibers.

    Main Methods:

    • Sciatic nerve transection and neuroma induction in Sprague-Dawley rats.
    • Ultrastructural analysis of neuroma tissue at multiple time points (7, 14, 30, 60 days).

    Main Results:

    • Normal configuration of unmyelinated nerve fibers and organelles observed.

    Related Experiment Videos

  • Degenerating fibers and neurofilament masses were frequent.
  • Approximately 10% of observed fascicles contained multiple unmyelinated nerve fibers within a single Schwann process.
  • Some of these multiple fascicles exhibited direct membranous apposition between axons.

    • Conclusions:

    • The presence of multiple unmyelinated axons within a single Schwann process, some in direct contact, provides an anatomical substrate for nerve fiber cross-talk.
    • This anatomical configuration may contribute to the generation of pain associated with neuromas.