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The developmental field concept in clinical genetics

J M Opitz

    The Journal of Pediatrics
    |November 1, 1982
    PubMed
    Summary

    Embryonic developmental fields coordinate complex structures, responding as a unit to disturbances. Understanding these fields is crucial for diagnosing and treating congenital anomalies.

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    Area of Science:

    • Developmental biology
    • Embryology
    • Teratology

    Background:

    • Embryonic development involves coordinated processes within specific regions called developmental fields.
    • Disturbances in these fields can lead to various congenital anomalies, ranging from severe to mild.
    • Identical malformations from different causes indicate structures acting as a single developmental unit.

    Purpose of the Study:

    • To elucidate the concept and significance of embryonic developmental fields.
    • To explain how disturbances within these fields result in malformations.
    • To highlight the importance of understanding developmental fields for clinical practice.

    Main Methods:

    • Review of evidence from comparative anatomy, embryology, and teratology.
    • Analysis of experimental embryology and developmental genetics findings.
    • Examination of malformation syndromes and their underlying field disturbances.

    Main Results:

    • Developmental fields exhibit spatially ordered, temporally synchronized, and hierarchically controlled development.
    • The timing and location of a developmental insult influence the severity of the resulting malformation.
    • Disruptions in long-distance inductive relationships can mimic malformation syndromes.

    Conclusions:

    • Developmental fields are fundamental units of embryonic organization.
    • Understanding field biology is essential for comprehending the etiology of congenital anomalies.
    • A deeper clinical understanding of developmental fields can improve care for malformed individuals and their families.

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