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Cytotoxicity of chloropeptide in isolated hepatocytes and its inactivation by microsomes
The Journal of Toxicological Sciences
|May 1, 1982
Abstract:
Chloropeptide, a hepatotoxic mycotoxin of Penicillium islandicum Sopp, induces gross changes in cell morphology including blebbing and ballooning of the cytoplasmic membrane in the isolated hepatocytes, and this hepatotoxic potential of chloropeptide is abolished by microsomal cytochrome P-450 system.