[Experimental and clinical studies on amoxicillin sustained-release preparation in the otorhinolaryngologic field]

Fundamental and clinical evaluations of a new continual penicillin, C-AMOX, were performed. The results obtained were as follows. 1. Concentration in serum: The level of serum concentration after giving 500 mg of oral C-AMOX was determined in 3 cases of health adult. The maximal level measured 4.8 micrograms/ml at 4 hours after oral administration. Even 8 hours after oral administration, clinically effective serum C-AMOX concentration 1.6 micrograms/ml was still demonstrable. 2. Concentration of tissues: At 4 hours after a single oral dose of 500 mg, the concentration in the tissues of palatine tonsilla was 0.6 microgram/g as against 4.9 micrograms/ml in the serum, and the concentration in the tissues of mucous membrane of maxillary sinus was 0.5 microgram/g when measured 4.6 micrograms/ml in the serum. 3. Results of clinical treatment: C-AMOX of oral administration was tested in 46 cases of usually encountered acute an chronic infections in the otorhinolaryngologic field, the results being excellent in 25 cases, good in 14 cases and fair in 6 cases. When the excellent and good were bracketed together, it amounts to 39 cases (84.8%). It can be considered as high effective ratio. No side effect was shown with the oral administration of C-AMOX.