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Serum high density lipoprotein cholesterol: as a cholesterol risk factor index for atherosclerotic diseases
Insights
This study found that the cholesterol risk factor index (CRFI) correlates with various health markers in adults. Sex and age significantly influence these relationships, highlighting the importance of personalized risk assessment for cardiovascular health.
Area of Science:
- Cardiovascular Health
- Biochemistry
- Public Health
Background:
- Atherosclerotic disorders, including ischemic heart disease, pose significant health risks.
- Serum lipid profiles, particularly high-density lipoprotein cholesterol (HDL-CHO), are crucial indicators of cardiovascular health.
- The cholesterol risk factor index (CRFI) is a valuable metric for assessing cholesterol-related health risks.
Purpose of the Study:
- To investigate the correlations between CRFI and various physiological factors in healthy adults.
- To examine the influence of sex and age on these correlations.
- To understand the relationship between HDL-CHO and CRFI.
Main Methods:
- Serum lipid profiles (HDL-CHO, total cholesterol, triglyceride) were measured in 342 males and 483 females.
- The cholesterol risk factor index (CRFI) was calculated as (total cholesterol-HDL.CHO)/total cholesterol.
- Correlations were analyzed between CRFI and factors including uric acid, erythrocyte count/components, obesity, blood pressure, and age.
Main Results:
- CRFI showed significant positive correlations with serum cholesterol, triglyceride, uric acid, erythrocyte count/components, obesity, and blood pressure in the combined male and female group.
- HDL-CHO was negatively correlated with CRFI.
- Sex and age influenced the strength and presence of these correlations; females exhibited more correlations with CRFI than males, and aging impacted CRFI and related factors more significantly in females.
Conclusions:
- CRFI is a significant index associated with multiple health factors, including lipid levels, uric acid, erythrocyte parameters, obesity, and blood pressure.
- The relationship between CRFI and these factors is modulated by sex and age.
- These findings underscore the importance of considering sex and age in the assessment and management of cardiovascular risk.
Abstract:
Serum high density lipoprotein cholesterol (HDL.CHO) of health individuals (342 males and 483 females) was measured with other serum lipid contents as well as several factors which may be possibly associated with atherosclerotic disorders including ischemic heart disease. As a cholesterol risk factor index (CRFI), (total cholesterol-HDL.CHO)/total cholesterol was studied. With the increase of CRFI in male plus female group, highly significant correlations were detected in the following factors: i.e. cholesterol, triglyceride, uric acid in serum; the number of erythrocytes and the components; obesity and blood pressure. HDL-CHO was negatively related to the increase of CRFI. In female, all these correlations to CRFI were found. In male, however, only 3 categories such as serum lipid components, the number of erythrocytes and obesity were related to CRFI. With the advance of age, significant changes were found mainly in female: in CRFI, cholesterol, triglyceride, uric acid, glucoxyloxal transferase, erythrocyte components, and blood pressure. In male, only the last two factors were correlated with aging. Thus, the relation of CRFI to other categories depended not only sex but also aging.