Histamine and some of its metabolites in human body fluids

The concentrations of histamine, t-methylhistamine and t-methylimidazoleacetic acid were measured in human cerebrospinal fluid, plasma and urine, Especially noteworthy are the levels of histamine in cerebrospinal fluid which are far higher than those of t-methylhistamine and of t-methylimidazoleacetic acid, and high enough to stimulate histamine receptors in the central nervous system. It is suggested that mast cells, which surround the subarachnoid space, may contribute histamine to the cerebrospinal fluid and may offer a target for drugs and for immunologic actions. The t-methylhistamine and t-methylimidazoleacetic acid levels in cerebrospinal fluid may reflect central histaminergic activity, although a source of these metabolites in addition to histamine needs to be considered.