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Sweat gland carcinoma with hypercalcemia
Journal of Surgical Oncology
|November 1, 1982
Summary
A recurrent malignant thigh tumor, likely from sweat glands, caused hypercalcemia. Surgical removal of the tumor led to the resolution of hypercalcemia, with the patient remaining symptom-free.
Area of Science:
- Oncology
- Endocrinology
- Surgical Pathology
Background:
- Malignant tumors can present with paraneoplastic syndromes, affecting systemic calcium homeostasis.
- Sweat gland carcinomas are rare malignancies with diverse clinical presentations.
- Hypercalcemia is a serious metabolic complication associated with various cancers.
Observation:
- A case of a large, recurrent malignant tumor of the thigh, suspected to be of sweat gland origin, is described.
- The tumor exhibited invasion into the periosteum of the pubis.
- The patient presented with significant hypercalcemia concurrently with the tumor.
Findings:
- Hypercalcemia resolved completely after surgical intervention (hemipelvectomy).
- The patient has remained asymptomatic since the procedure in 1977, indicating successful tumor eradication.
- Histopathological confirmation of sweat gland origin would further clarify the tumor's nature.
Implications:
- This case highlights the potential for rare malignant tumors to cause metabolic disturbances like hypercalcemia.
- It underscores the importance of considering paraneoplastic syndromes in patients with unexplained hypercalcemia and a history of malignancy.
- Successful surgical management can lead to long-term remission even in aggressive, recurrent tumors.