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Related Experiment Videos

[Persisting suppression of hyperprolactinemia after bromcriptine withdrawal]

P Drobnjak, V Simunić, I Puharić

    Jugoslavenska Ginekologija I Opstetricija
    |January 1, 1982
    PubMed
    Summary

    Parlodel effectively treated a patient with a pituitary macroprolactinoma, normalizing prolactin levels and restoring menstrual cycles. The patient later conceived and delivered a healthy baby without tumor growth.

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    Area of Science:

    • Endocrinology
    • Reproductive Medicine

    Background:

    • Macroprolactinoma, a pituitary tumor, can cause secondary amenorrhea and galactorrhea.
    • Hyperprolactinemia is a common endocrine disorder associated with pituitary adenomas.

    Purpose of the Study:

    • To report the successful management of a patient with a pituitary macroprolactinoma using Parlodel (bromocriptine).
    • To evaluate the efficacy of Parlodel in normalizing prolactin levels, restoring reproductive function, and managing tumor size.

    Main Methods:

    • A 22-year-old patient with secondary amenorrhea, galactorrhea, and pituitary macroprolactinoma was treated with Parlodel.
    • Dosage was adjusted from 20 mg daily to 2.5 mg intermittently until ovulation.

    Main Results:

    • Treatment normalized prolactin levels and restored regular menstrual cycles within 34 months.

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  • The patient conceived 5 months after therapy cessation, with normal prolactin during pregnancy and no tumor growth.
  • Post-lactation, hyperprolactinemia persisted at a significantly reduced level (29.1-34.4% of baseline).

    • Conclusions:

    • Parlodel is an effective treatment for pituitary macroprolactinoma, achieving hormonal normalization and restoring fertility.
    • Intermittent, ovulation-targeted dosing may be a viable strategy for managing hyperprolactinemia and facilitating conception.
    • Long-term management may be necessary, even after successful pregnancy, to control residual hyperprolactinemia.