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A quality assurance programme for quantitative urine analyses

M D Shephard, L A Penberthy, C G Fraser

    Pathology
    |July 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    This quality assurance program assessed 10 urine analytes across 86 labs. While creatinine and glucose showed good performance, sodium, potassium, and urea analyses require significant improvement for accurate patient results.

    Area of Science:

    • Clinical Chemistry
    • Laboratory Medicine
    • Quality Assurance

    Background:

    • Interlaboratory quality assurance programs are crucial for standardizing diagnostic testing.
    • Evaluating performance across multiple laboratories ensures reliable patient results for urine analytes.
    • Previous assessments highlighted variability in urine analyte measurements, necessitating a comprehensive review.

    Purpose of the Study:

    • To assess the performance of 86 Australasian laboratories in quantifying 10 key urine analytes.
    • To identify analytical methods and laboratory practices that require improvement for accurate urine testing.
    • To provide timely feedback to participating laboratories regarding their performance against established quality goals.

    Main Methods:

    • Eighty-six laboratories analyzed 12 liquid urine samples prepared from commercial control materials.

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  • Samples were distributed in three batches, with concentrations linearly related for simplified analysis.
  • Pre-set total laboratory error limits and target values were used for graphic feedback and performance comparison.

    • Main Results:

    • Performance varied significantly across the 10 urine analytes.
    • Laboratories met analytical goals for urine creatinine, phosphate, urate, and glucose.
    • Significant improvements are needed for urine sodium, potassium, urea, calcium, osmolality, and protein analyses.

    Conclusions:

    • While some urine analytes are measured reliably, others require substantial improvement in laboratory performance.
    • Future efforts should focus on better calibration, quality control materials, error reduction, and analysis of high-concentration samples.
    • Enhanced quality assurance is vital for improving the accuracy and reliability of routine urine diagnostic testing.