Activation of Trp-P-1 and Trp-P-2 in vitro and in vivo

Isolated perfused livers were not able to activate the promutagens Trp-P-1 and Trp-P-2 to their genotoxic metabolites. On the contrary, inherently active mutagenic compounds were detected in the bile of living rats to which Trp-P-1 and Trp-P-2 had been administered intravenously. The excretion of active mutagens through the bile may explain the tumorigenic effect that these compounds exert on the liver during chronic feeding experiments.