Electrodermal activity and therapeutic response to neuroleptic treatment in chronic schizophrenic in-patients

Electrodermal measures, psychiatric ratings (Brief Psychiatric Rating Scale, Clinical Global Impressions) and several Wechsler subtest scores were obtained for 26 hospitalized chronic schizophrenics during drug 'washout'. The psychiatric ratings and Wechsler scores were obtained again after 6 months' treatment with thiothixene or thioridazine. Results revealed that those patients who displayed therapeutic benefit from the neuroleptic treatment displayed greater pre-treatment electrodermal activity and higher skin conductance levels, compared with schizophrenics who did not benefit. No effect for laterality was noted.