[Blood coagulation state on exposure to prolonged hypokinesia]

The effect of 14- and 30-day hypokinesia on hemocoagulation of rabbits was studied. Hypokinesia caused noticeable changes in the hemostatic system. By the 14th hypokinetic day the experimental animals developed hypercoagulation which in some cases ended in intravascular blood-clotting. By the 30th hypokinetic day there was a decrease in the total blood coagulatory capability which to be associated with the utilization of procoagulants during blood clotting and an increase in the anticoagulant activity in response to primary hypercoagulemia. Thus, hypokinesia-induced changes in the blood clotting system develop like the thrombohemorrhagic syndrome.