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Related Experiment Videos

Trisomy 13 in the mouse

K Hongell, A Gropp

    Teratology
    |August 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Trisomy 13 (Ts 13) in fetal mice causes significant growth retardation, developmental delays, and malformations like cleft palate. Impaired cell proliferation is suggested as the underlying cause of these developmental issues.

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    Area of Science:

    • Developmental Biology
    • Genetics
    • Teratology

    Background:

    • Trisomy 13 (Ts 13) is a chromosomal abnormality.
    • Understanding its impact on fetal development is crucial.

    Purpose of the Study:

    • Investigate fetal development in mice with trisomy 13.
    • Identify key developmental abnormalities and their potential causes.

    Main Methods:

    • Produced Ts 13 mouse fetuses using Robertsonian translocation.
    • Monitored fetal development from day 12 to 19 of gestation.
    • Analyzed fetal size, weight, ossification, and malformations.

    Main Results:

    • Ts 13 fetuses exhibited significant growth retardation and hypoplasia.

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  • A 1-1.5 day delay in general development and ossification was observed.
  • 86% of Ts 13 fetuses presented with cleft palate; edema was also noted.

    • Conclusions:

    • Ts 13 leads to severe fetal growth retardation and developmental delays.
    • Impaired trisomic cell proliferation may underlie hypoplasia and malformations.
    • This cellular mechanism could also impact placental development.