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Related Experiment Videos

Radiological pituitary fossa changes in chronic bronchitis

P D Semple, P Macpherson

    Thorax
    |July 1, 1982
    PubMed
    Summary

    Chronic bronchitis patients often show pituitary fossa abnormalities on X-rays, possibly linked to hypoxia. These changes, including lamina dura thinning, are not solely due to high intracranial pressure.

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    Area of Science:

    • Radiology
    • Pulmonary Medicine
    • Endocrinology

    Background:

    • Chronic bronchitis is associated with hypoxia and hypercapnia.
    • Pituitary fossa abnormalities have been anecdotally reported in chronic bronchitis.
    • The exact cause of these changes remains unclear.

    Purpose of the Study:

    • To investigate the frequency and nature of pituitary fossa abnormalities in male patients with chronic bronchitis and hypoxia.
    • To compare findings with a control group.
    • To explore potential contributing factors such as hypercapnia and hypoxia.

    Main Methods:

    • Lateral radiographs of the pituitary fossa were obtained from 14 male patients with chronic bronchitis and hypoxia.
    • A control group of 14 age-matched men with head injuries was used for comparison.
    • Statistical analysis was performed to determine the significance of observed differences.

    Main Results:

    • Nine out of 14 (64%) chronic bronchitis patients had definite or probable pituitary fossa abnormalities, significantly higher than the control group (p <= 0.01).
    • The most common abnormality was thinning or erosion of the lamina dura.
    • No significant difference in abnormality frequency was observed between patients with hypercapnia and normocapnia.

    Conclusions:

    • Radiological pituitary fossa changes are common in chronic bronchitis patients with hypoxia.
    • These changes are unrelated to steroid treatment.
    • Hypoxia, potentially via increased cerebral blood flow and intracranial blood engorgement, is a likely contributing factor, rather than solely chronically raised intracranial pressure from hypercapnia.

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