[Effect of protease inhibitors on influenza virus reproduction]

Natural inhibitors of proteases have been shown to inhibit plaque production by influenza virus. Investigation of the fate of viral intracellular proteins revealed the inhibiting effect of these inhibitors on their posttranslation cutting. It is assumed, therefore, that the antiviral effect of the preparation under study is associated with inhibition of viral proteins cutting, in particular, of hemagglutinin. A comparative study of the antiviral activity of inhibitors of proteases from various sources was carried out: from potato, haricot, common honey locust, as well as trypsin inhibitor from soybeans. The highest antiviral activity determined by the plaque reduction test was found with the preparation obtained from potato.