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Related Experiment Videos

'Loads' alert

A M Khajawall, J J Sramek, G M Simpson

    The Western Journal of Medicine
    |August 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    New drug abuse trends show "Loads," a glutethimide and codeine combination, is rising in Los Angeles as a heroin substitute. This drug poses risks of serious intoxication and complex withdrawal symptoms, requiring specialized detoxification.

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Addiction Medicine

    Background:

    • Emerging drug abuse trends highlight the rise of "Loads," a combination of glutethimide and codeine.
    • This substance is increasingly used as a heroin substitute, particularly in the Los Angeles area.
    • Preliminary data suggests a growing public health concern associated with this drug combination.

    Purpose of the Study:

    • To investigate the clinical profile of "Loads" abuse.
    • To identify potential intoxications and withdrawal complications associated with glutethimide and codeine abuse.
    • To inform appropriate detoxification strategies for individuals abusing "Loads".

    Main Methods:

    • The study involved interviews and treatment of individuals identified as preferential "Loads" abusers.

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  • Data was collected over a one-year period.
  • Analysis focused on observed intoxication and withdrawal symptoms.

    • Main Results:

    • "Loads" abuse is associated with a significant potential for serious intoxications.
    • Withdrawal symptoms observed were complex, reflecting both sedative-hypnotic and narcotic effects.
    • A pattern of abuse and associated complications was identified in the studied population.

    Conclusions:

    • The combination of glutethimide and codeine presents a unique and serious drug abuse challenge.
    • Effective detoxification requires a plan that addresses the dual pharmacologic actions of the abused substances.
    • Further research is warranted to fully understand the long-term implications of "Loads" abuse.