[Penetration of antibiotics into peripheral infection foci]

The general pharmacokinetics of first order open one- and two-compartment models are given. Particular attention is drawn to the penetration of peripheral foci by antibiotics. The amount of a substance transported to a focus of infection is proportional to the area under the plasma concentration curve. The peak in peripheral foci appears somewhat later than in the plasma and is a little lower. However, when substances are excreted rapidly from the body the level in peripheral foci often remains above the serum level towards the end of the dosage interval. Intermittent administration achieves a higher peripheral concentration than a continuous infusion of the same dosage.