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[Polymorphism of articular chondrocalcinosis]
Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|July 1, 1982
Summary
Articular chondrocalcinosis, caused by calcium pyrophosphate dihydrate crystal deposition in cartilage, presents varied symptoms and is increasingly recognized. This condition requires careful diagnosis to differentiate it from other joint diseases.
Area of Science:
- Rheumatology
- Orthopedics
- Crystal Arthropathies
Background:
- Articular chondrocalcinosis involves calcium pyrophosphate dihydrate crystal deposition in joint cartilage.
- It presents with diverse clinical manifestations, including monoarticular, oligoarticular, and polyarticular involvement, potentially affecting spinal discs.
- Radiographic calcification is characteristic but not definitive for diagnosis.
Purpose of the Study:
- To provide a comprehensive overview of articular chondrocalcinosis.
- To discuss its clinical presentation, hereditary patterns, diagnostic approaches, and pathogenesis.
- To highlight its differential diagnostic significance in joint diseases.
Main Methods:
- Literature review on articular chondrocalcinosis.
- Synthesis of current knowledge on clinical features, genetics, diagnostics, and pathogenesis.
- Analysis of differential diagnostic considerations.
Main Results:
- Chondrocalcinosis exhibits varied symptomatology and can occur in familial or spontaneous forms, particularly in individuals over 50.
- It is observed in 3% of postmortem examinations.
- The condition is relevant in differentiating from primary osteoarthritis, gout, and rheumatoid arthritis.
Conclusions:
- Articular chondrocalcinosis is a condition of growing clinical importance.
- Accurate diagnosis is crucial, especially considering its symptomatic association with hyperparathyroidism and hemochromatosis.
- Further understanding of its pathogenesis and clinical spectrum is warranted.