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Summary
Bowen's disease at the limbus, a form of squamous cell carcinoma in situ, presents in papillomatous, leukoplakic, or gelatinous forms. Combined excision and cryotherapy effectively prevented recurrence, unlike excision alone.
Area of Science:
- Ophthalmology
- Dermatology
- Oncology
Background:
- Bowen's disease (squamous cell carcinoma in situ) can affect the ocular surface.
- Understanding its clinical presentation and treatment outcomes is crucial for patient management.
Observation:
- Ten cases of limbal Bowen's disease were clinicopathologically studied.
- Clinical features were categorized into papillomatous, leukoplakic, and gelatinous forms.
- Histopathological analysis revealed no significant differences between these clinical forms.
Findings:
- Excision and cryotherapy resulted in no recurrence in 8 cases over 1.5 to 9 years.
- Two cases treated with excision alone showed recurrence and malignant progression in one instance.
Implications:
- Combined surgical excision and cryotherapy appear to be an effective treatment for limbal Bowen's disease.
- Early and aggressive treatment may be necessary to prevent recurrence and malignant transformation.