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Drug therapy in otomycosis: an in vitro study
The Laryngoscope
|November 1, 1978
Summary
Otomycosis, a fungal ear infection, often lacks specific treatments. This study found nystatin and clotrimazole effective against fungi, offering targeted therapy options for otomycosis.
Area of Science:
- Otolaryngology
- Mycology
- Infectious Diseases
Background:
- Otomycosis, a fungal external otitis, presents a persistent clinical challenge.
- Unlike bacterial infections, effective otic preparations with specific antifungal activity are lacking for otomycosis.
Purpose of the Study:
- To evaluate the in vitro antimicrobial and antifungal activity of various otic preparations.
- To identify effective therapeutic options for otomycosis.
Main Methods:
- An agar-disc diffusion assay was employed.
- Tested preparations against common bacterial species causing external otitis and various yeast and filamentous fungi.
Main Results:
- Aqueous Merthiolate and Cresylate exhibited broad-spectrum antimicrobial activity.
- Nystatin and clotrimazole demonstrated specific and potent antifungal activity against tested fungal species.
Conclusions:
- Nystatin and clotrimazole are effective in vitro against fungi implicated in otomycosis.
- These findings support the use of specific antifungal otic preparations as an alternative to empirical treatments for otomycosis.
