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Program for aminoglycoside dosage calculations using an inexpensive calculator

J P Gee, L K Jim

    American Journal of Hospital Pharmacy
    |September 1, 1982
    PubMed
    Summary

    A new program for pocket calculators simplifies aminoglycoside (gentamicin and tobramycin) dosing. This tool accurately predicts drug levels, aiding in safe and effective patient treatment.

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    Area of Science:

    • Pharmacokinetics and Pharmacodynamics
    • Clinical Pharmacy
    • Medical Informatics

    Background:

    • Aminoglycoside dosing requires precise calculations to ensure efficacy and minimize toxicity.
    • Traditional methods can be time-consuming and prone to error.
    • Pocket-size programmable calculators offer a portable solution for complex calculations.

    Purpose of the Study:

    • To develop and evaluate a programmable calculator program for gentamicin and tobramycin dosage calculations.
    • To simplify the process of determining optimal aminoglycoside dosing regimens.
    • To predict key pharmacokinetic parameters and drug concentrations accurately.

    Main Methods:

    • Developed a program based on a first-order one-compartment pharmacokinetic model for a Sharp EL-5813 calculator.
    • Included functions for loading/maintenance doses, peak/trough concentrations, elimination constant, creatinine clearance, and volume of distribution.
    • Evaluated the program by comparing predicted versus observed gentamicin plasma concentrations in 24 patients.

    Main Results:

    • The program demonstrated a significant correlation between predicted and observed steady-state peak and trough plasma concentrations.
    • Programming the calculator took less than 30 seconds.
    • Each dosage and concentration calculation averaged approximately 2.5 minutes.

    Conclusions:

    • The developed calculator program offers a simple, accurate, and efficient method for aminoglycoside dosage recommendations.
    • It facilitates reliable predictions of peak and trough plasma concentrations.
    • This tool can improve the safety and effectiveness of aminoglycoside therapy.

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