Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neonatal seizures and subsequent epilepsy

K Watanabe, M Kuroyanagi, K Hara

    Brain & Development
    |January 1, 1982
    PubMed
    Summary

    Neonatal seizures can lead to epilepsy, especially with central nervous system (CNS) dysgenesis. Abnormal neonatal electroencephalograms (EEGs) correlate with increased seizure frequency in infants with perinatal brain injury.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1.

    The Journal of biological chemistry·1992
    Same author

    Development and characterization of Porphyromonas gingivalis-specific rat T-cell clones.

    Archives of oral biology·1992
    Same author

    [Tumor associated carbohydrate antigens in bronchoalveolar lavage fluid in patients with diffuse panbronchiolitis].

    Nihon Kyobu Shikkan Gakkai zasshi·1992
    Same author

    [Analysis of urinary tract infections in hospitalized elderly patients, with particular reference to the use of diapers].

    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases·1992
    Same author

    [DNA probe and polymerase chain reaction for detection and identification of mycobacteria].

    Kekkaku : [Tuberculosis]·1992
    Same author

    A rare case of extramedullary plasmacytoma in the mediastinum.

    Internal medicine (Tokyo, Japan)·1992

    Area of Science:

    • Neurology
    • Neonatology
    • Epileptology

    Background:

    • Epileptic seizures in newborns are a significant concern.
    • Understanding the long-term outcomes of neonatal seizures is crucial for early intervention.
    • Identifying risk factors for developing epilepsy after neonatal seizures is essential.

    Purpose of the Study:

    • To describe the neonatal findings and long-term epilepsy development in newborns experiencing seizures.
    • To investigate the relationship between specific neonatal conditions and the subsequent risk of epilepsy.
    • To analyze electroencephalographic (EEG) patterns and their correlation with epilepsy development.

    Main Methods:

    • Retrospective analysis of newborns with neonatal seizures.
    • Classification of neonatal conditions including CNS dysgenesis, perinatal hypoxia, birth injury, and meningitis.
    • Correlation of neonatal neurological and EEG findings with the later development of epilepsy.

    Main Results:

    • Neonates with CNS dysgenesis had the highest risk (80%) of developing epilepsy.
    • Approximately 30% of infants with perinatal hypoxia/birth injury or meningitis developed epilepsy.
    • More abnormal neonatal neurological and EEG findings were associated with epilepsy development in perinatal brain injury cases.
    • Abnormal neonatal background EEG predicted more frequent later epileptic fits, but not in CNS dysgenesis.
    • Myoclonic seizures indicated severe brain damage; West syndrome was linked to very abnormal neonatal EEGs.

    Conclusions:

    • Neonatal seizures, particularly in the context of CNS dysgenesis or perinatal brain injury, significantly increase the risk of developing epilepsy.
    • Neonatal EEG abnormalities are important predictors of epilepsy development and seizure frequency.
    • Specific seizure types and EEG patterns in the neonatal period can indicate the severity of brain damage and prognosis.

    Related Experiment Videos