Coronary artery distribution in bonnet monkeys (Macaca radiata)

Area of Science:

• Comparative anatomy
• Cardiovascular research
• Primate models

Background:

• Coronary vascular disease research requires suitable animal models.
• Nonhuman primate models are valuable but lack detailed coronary anatomy data.
• Bonnet monkeys (Macaca radiata) are potential models for human cardiovascular studies.

Purpose of the Study:

• To delineate the gross coronary arterial anatomy of the Bonnet monkey.
• To assess the suitability of Bonnet monkeys as a model for coronary vascular disease research.

Main Methods:

• Postmortem coronary angiography was performed on 16 adult male Bonnet monkey hearts.
• Gross morphological examination of the coronary arterial system was conducted.

Main Results:

• The main left coronary artery bifurcated into the left anterior descending (LAD) and left circumflex (LCA) coronary arteries.
• The posterior descending coronary artery (PDCA) originated from the LCA in 31% and RCA in 56% of hearts.
• Sinoatrial and atrioventricular node arterial supply patterns were identified, with similarities to human anatomy.

Conclusions:

• Bonnet monkey coronary anatomy shares significant similarities with human coronary anatomy.
• The Bonnet monkey serves as a relevant model for specific coronary circulation pathophysiological studies.
• This detailed anatomical data supports the use of Bonnet monkeys in cardiovascular research.