Interrelationship between several prognostic factors in Hodgkin's disease

Material of 150 patients with Hodgkin's disease was demonstrated and analyzed as to the prognostic significance of factors such as clinical advancement of the disease, histology, sex and age. Median survival time differed significantly in various clinical stages, being in I-III A stages as long as 8.0 years, in III B--5.5 and in IV B--3.4. Median survival time in relative to histologic pattern did not differ significantly in spite of fact that that of LD form was about 2 years shorter than of 3 remaining types. Mean but not median survival time of women was significantly longer than that of men: women were at presentation at less advanced clinical stages and in LD type showed more favourable clinical course than men, but not in NS type. Presence of systemic symptoms was also determinant of worse prognosis. It was observed that simultaneous incidence of unfavourable prognostic factor as LD histology, male sex and advanced clinical stage markedly worsened prognosis.