Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Ocular toxicity associated with high-dose carmustine

B J Shingleton, D C Bienfang, D M Albert

Archives of Ophthalmology (Chicago, Ill. : 1960)

|November 1, 1982

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Glaucoma and intraocular lenses-evolving concepts in implantation and in management of complications.

Journal of glaucoma·2009

Same author

Visual deficits in a patient with 'kaleidoscopic disintegration of the visual world'.

European journal of neurology·2002

Same author

Glaucoma surgery treatment patterns of ASCRS members--2000 survey.

Journal of cataract and refractive surgery·2001

Same author

Anterior chamber maintainer versus viscoelastic material for intraocular lens implantation: case-control study.

Journal of cataract and refractive surgery·2001

Same author

Evaluation of intraocular pressure in the immediate period after phacoemulsification.

Journal of cataract and refractive surgery·2001

Same author

Blurred vision.

The New England journal of medicine·2000

Same journal

The economics of the initial preventive physical examination in medicare-reply.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013

Same journal

Modification of silicone oil retention sutures in aphakic eyes with iris loss-reply;.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013

Same journal

December 2011 archives web quiz winner.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013

Same journal

Angle involvement and glaucoma in patients with biopsy-proven iris melanoma: a response-reply.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013

Same journal

About this journal.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013

Same journal

In memoriam: goodwin m. Breinin, MD (1918-2011).

Archives of ophthalmology (Chicago, Ill. : 1960)·2013

See all related articles

Carmustine, a nitrosourea, can cause delayed ocular toxicity in patients undergoing high-dose chemotherapy. This includes vision loss and retinal changes, particularly with intra-arterial administration.

Area of Science:

Ophthalmology
Oncology
Pharmacology

Background:

Carmustine (BCNU) is a nitrosourea chemotherapy agent.
Ocular side effects of carmustine are not well-established.
High-dose carmustine is used with autologous bone marrow rescue.

Observation:

Delayed bilateral ocular toxicity occurred in 2/50 patients receiving high-dose intravenous carmustine.
Delayed ocular toxicity occurred ipsilaterally in 7/10 patients receiving intra-arterial carotid carmustine.
Ocular toxicity symptoms appeared 4 weeks post-IV and 2-14 weeks post-intra-arterial treatment.

Findings:

Funduscopic findings included arterial narrowing, nerve fiber-layer infarcts, and intraretinal hemorrhages.
Fluorescein angiography showed perivascular staining, capillary leakage, and optic disc hyperfluorescence.

Related Experiment Videos

One patient experienced cilioretinal artery occlusion and choroidal fibrin thrombi.

Implications:

High-dose carmustine, especially via intra-arterial route, poses a risk of significant ocular toxicity.
Ocular toxicity can manifest as severe vision loss.
Further research is needed to understand and mitigate carmustine-induced ocular complications.