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[Antithrombin III in infantile nephrotic syndrome]
Bollettino Della Societa Italiana Di Biologia Sperimentale
|September 15, 1982
Summary
In Nephrotic Syndrome, low Antithrombin III (AT-III) levels are linked to hypercoagulability, impacting disease course. This study confirms AT-III
Area of Science:
- Pediatric Nephrology
- Hematology
- Coagulation Disorders
Context:
- Nephrotic Syndrome (NS) is associated with an increased risk of thromboembolic events.
- A hypercoagulable state is a known complication of NS.
- Antithrombin III (AT-III) deficiency has been hypothesized as a cause of this hypercoagulability.
Purpose:
- To investigate the correlation between plasma Antithrombin III (AT-III) concentration and clinical parameters in children with Nephrotic Syndrome.
- To assess the relationship between AT-III levels, serum albumin, proteinuria, and Partial Thromboplastin Time (PTT).
Summary:
- Plasma AT-III concentration was measured in 24 children with NS.
- Significant correlations were found between AT-III levels, serum albumin, proteinuria, and PTT.
- Lower AT-III levels were particularly observed in patients with relapsed disease and those who developed venous thrombosis.
Impact:
- This study highlights the clinical significance of AT-III levels in managing Nephrotic Syndrome.
- Findings support the role of AT-III deficiency in the hypercoagulability associated with NS.
- Understanding these correlations may aid in predicting and preventing thromboembolic complications in pediatric NS patients.