[Na+ and K+ in the rabbit aqueous humor after treatment with timolol]

The influence of timolol on aqueous humour production has been well documented, nevertheless it is unknown the real mechanism by which timolol produces this process. We have conceived the hypothesis that any alteration of natrium and kalium content following topical treatment of timolol was the main cause of the lowering rate of aqueous humour production. Therefore, we have examined the behaviour of Na+ and K+ amounts after topical administration of one eye of young rabbits with timolol. The experimentation has been conducted by photometer appliance. Our results show the absence of any imbalance between natrium and kalium content. The failure of our purpose indicates that Na+/K+ content does not play a main role in decreasing aqueous humour production by timolol.