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Related Experiment Videos

Regional lung ventilation in ankylosing spondylitis

A Parkin, P J Robinson, P Hickling

    The British Journal of Radiology
    |November 1, 1982
    PubMed
    Summary

    Ankylosing spondylitis (AS) patients do not show reduced upper lung ventilation unless apical fibrosis is present. Thoracic rigidity in AS does not inherently cause underventilation in lung zones.

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    Area of Science:

    • Pulmonary Medicine
    • Rheumatology
    • Radiology

    Background:

    • Ankylosing spondylitis (AS) can lead to apical lung fibrosis and cavitation.
    • Reduced apical ventilation due to thoracic cage rigidity is a suspected cause.

    Purpose of the Study:

    • To investigate regional lung ventilation in AS patients.
    • To determine if thoracic rigidity in AS affects upper vs. lower lung ventilation.

    Main Methods:

    • Measured regional ventilation using 81Krm washout curves in 27 AS patients and 18 controls.
    • Calculated the upper to lower zone ventilation ratio (VR).
    • Grouped patients based on chest expansion and presence of lung lesions.

    Main Results:

    • No significant difference in VR was found between AS patient groups (with or without significant chest expansion) and controls.
    • No correlation existed between VR and lung function tests (FVC, FEV1) or chest expansion.
    • Reduced ventilation was localized to radiographically abnormal areas in patients with apical fibrosis.

    Conclusions:

    • Ankylosing spondylitis patients do not exhibit generalized upper zone underventilation.
    • Reduced ventilation in AS is linked to the presence of radiographically visible apical fibrosis, not thoracic rigidity alone.

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