Lateral hypothalamus neuron responses to electroosmotic 2-deoxy-D-glucose

Electroosmotic applications of 2-deoxy-D-glucose (2-DG) were made in the lateral hypothalamus (LHA). Changes in LHA unit activity and concomitant gastric acid secretion were then observed 2-DG responsive neurons tended to form two clusters in the LHA. Electroosmotic application induced four patterns of activity change in different LHA neurons. Gastric acid secretion increased when LHA unit activity increased. Results presented here agree with prior reports of hypophagia after precise lesions in this LHA region and other reports of 2-DG induced hyperphagia which might be mediated through central neurons.