Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synaptic organisation and neuron microtubule distribution

E G Gray, L E Westrum, R D Burgoyne

    Cell and Tissue Research
    |January 1, 1982
    PubMed
    Summary

    Researchers classified neuronal microtubules into eight categories based on stability, structure, and orientation. This classification aids understanding of their roles in vesicle transport and cytoskeletal support within neurons and synaptosomes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A magnetic massive star has experienced a stellar merger.

    Science (New York, N.Y.)·2024
    Same author

    Long-term water quality monitoring in agricultural catchments in Sweden: Impact of climatic drivers on diffuse nutrient loads.

    The Science of the total environment·2022
    Same author

    A challenge of being tall: an occupational cause of notalgia paraesthetica.

    Clinical and experimental dermatology·2021
    Same author

    Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology.

    Molecular psychiatry·2016
    Same author

    The fine structure of the vertical lobe of octopus brain.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2012
    Same author

    Glomerular filtration rate is a major determinant of the relationship between 25-hydroxyvitamin D and parathyroid hormone.

    Calcified tissue international·2007

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Cytoskeletal Dynamics

    Background:

    • Microtubules are crucial cytoskeletal components in neurons, involved in axonal transport and maintaining neuronal structure.
    • Understanding the heterogeneity of microtubules within different neuronal compartments, such as axons, dendrites, and synaptosomes, is essential for elucidating their specific functions.

    Purpose of the Study:

    • To classify and characterize microtubules in various neuronal compartments and synaptosomes.
    • To investigate the stability, structure, and orientation of different microtubule populations.
    • To explore the functional implications of microtubule diversity in neuronal processes.

    Main Methods:

    • Comparative analysis of microtubule characteristics using electron microscopy.
    • Tannic acid staining to reveal protofilament substructure differences.
    • Examination of microtubules in different neuronal regions and isolated synaptosomes.

    Main Results:

    • Microtubules were categorized into eight distinct classes based on observed differences in stability, lability, and protofilament substructure.
    • Specific distributions and orientations of microtubule types were identified in neuronal processes and synaptosomes.
    • Variations in microtubule characteristics correlate with their potential roles in cellular functions.

    Conclusions:

    • The study establishes a novel classification system for neuronal microtubules, highlighting their structural and functional diversity.
    • This classification provides a framework for understanding how different microtubule populations contribute to neuronal function, including vesicle transport and cytoskeletal organization.
    • Further research can leverage this classification to investigate specific microtubule roles in neuronal health and disease.

    Related Experiment Videos