Relation between tolerance dose and treatment field size in radiotherapy
Related Experiment Video
Updated: Oct 9, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
Abstract:
A relation is developed between tolerance dose and field size from an analysis of available clinical data on skin-tolerance doses for various treatment field sizes in radiotherapy. It is shown that plots of log-dose against log-field-size for various fractionation schedules give isoeffect lines all having approximately the same slope. This suggests a power law relation between tolerance dose and field size. A generalized form of NSD equation, incorporating the field-size dependence of tolerance dose, is shown to follow naturally when this new relation is combined with Ellis' NSD relation. Certain discrepancies between the sets of data used in the present analysis are pointed out and it is suggested that more data are needed before the generalized NSD relation can be applied under varying conditions of dose, time, fractionation, and field size.
More Related Videos
08:34Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
07:57Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
Published on: March 24, 2022
Related Concept Videos
Dosage Regimens: Designs and Approaches
Dosage Regimen: Individualization
Dose Size and Dosing Frequency: Determination Methods
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant