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The effect of renal failure and hemodialysis on serum and urine myoglobin
Insights
Patients with chronic kidney disease have elevated serum and urine myoglobin. Hemodialysis does not significantly reduce myoglobin levels, indicating it is not effectively removed by dialysis in end-stage renal disease patients.
Area of Science:
- Nephrology
- Biochemistry
Background:
- Chronic renal disease is associated with elevated myoglobin levels in serum and urine.
- The dialyzability of myoglobin in patients with end-stage renal disease is not well understood.
Purpose of the Study:
- To investigate the concentration of myoglobin in patients with chronic renal disease.
- To determine the effect of hemodialysis on serum myoglobin levels.
- To assess the dialyzability of myoglobin.
Main Methods:
- Serum and urine myoglobin concentrations were measured in 33 patients with chronic renal disease and compared to normal controls.
- Serum myoglobin levels were assessed before and after hemodialysis.
- Myoglobin levels in blood entering and leaving the dialysis coil, as well as in the dialyzate, were measured.
Main Results:
- Serum and urine myoglobin concentrations were significantly higher in patients with chronic renal disease compared to normal controls.
- Hemodialysis did not significantly lower serum myoglobin levels in patients with end-stage renal disease.
- No significant difference in serum myoglobin was observed in blood entering and leaving the dialysis coil.
- Myoglobin was not detectable in the dialyzate, indicating it is not appreciably removed by dialysis.
Conclusions:
- The association between chronic renal failure and elevated serum and urine myoglobin is confirmed.
- Myoglobin is not effectively removed by hemodialysis.
- Abnormally high myoglobin levels in chronic renal failure do not necessarily result in myoglobinuric renal failure.
Abstract:
In 33 patients with chronic renal disease, the concentration of myoglobin in serum and urine was found to be significantly elevated over that of normal controls. Hemodialysis had no statistically significant effect in lowering the serum myoglobin of patients with end stage renal disease. Similarly, no difference was found in serum myoglobin in blood entering and leaving the dialysis coil. Since myoglobin was not detectable in the dialyzate, these data illustrate that myoglobin is not appreciably dialyzable. The association between chronic renal failure and high concentration of serum and urine myoglobin was confirmed. These abnormally high levels of myoglobin in serum and urine do not necessarily lead to myoglobinuric renal failure.