Related Experiment Video

Updated: Jul 25, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

Eosinophilic gastroenteritis in the pediatric patient

L P Kravis, M A South, M L Rosenlund

    Clinical Pediatrics
    |December 1, 1982
    PubMed

    Insights

    Eosinophilic gastroenteritis, a rare condition causing abdominal pain and high eosinophil counts, requires careful diagnosis to avoid unnecessary surgery. This case highlights a 20-year successful treatment with prednisone.

    Area of Science:

    • Gastroenterology
    • Immunology
    • Pediatrics

    Background:

    • Eosinophilic gastroenteritis presents with abdominal complaints and peripheral eosinophilia.
    • Accurate diagnosis is crucial to prevent unnecessary exploratory surgeries.
    • This condition can affect individuals of all ages, including infants.

    Purpose of the Study:

    • To present a case study of a patient diagnosed with eosinophilic gastroenteritis.
    • To emphasize the importance of definitive diagnosis in managing the condition.
    • To review the literature on diffuse, infiltrative eosinophilic gastroenteritis.

    Main Methods:

    • A case report of an infant presenting with severe abdominal symptoms and marked eosinophilia.
    • Diagnostic procedures included peripheral blood count and antral tissue biopsy.
    • Exclusionary tests were performed to rule out other potential diagnoses.

    Main Results:

    • The patient was diagnosed with eosinophilic gastroenteritis based on biopsy findings and clinical presentation.
    • Eosinophilic ascites was noted.
    • Long-term management with intermittent prednisone courses resulted in sustained symptom control over 20 years.

    Conclusions:

    • Eosinophilic gastroenteritis is a significant diagnosis in patients with unexplained abdominal symptoms and eosinophilia.
    • Prompt and accurate diagnosis through biopsy is essential for appropriate management.
    • Prednisone can be an effective treatment for long-term symptom control in eosinophilic gastroenteritis.

    More Related Videos

    Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates08:32

    Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

    Published on: February 17, 2023

    Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis03:23

    Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

    Published on: May 10, 2024

    Related Concept Videos

    Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

    Endoscopic Procedures I: Esophagogastroduodenoscopy

    An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
    During an EGD, the endoscope can be used to:
    Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

    Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

    Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
    Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

    Pharmacokinetics in Pediatric Patients: Drug Metabolism

    In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
    Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

    Pharmacokinetics in Pediatric Patients: Drug Excretion

    In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
    Bacterial Gastroenteritis01:18

    Bacterial Gastroenteritis

    Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
    Giardiasis01:12

    Giardiasis

    Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...