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Related Experiment Videos

Propranolol dosage, plasma concentration, and beta blockade

J F Mullane, J Kaufman, D Dvornik

    Clinical Pharmacology and Therapeutics
    |December 1, 1982
    PubMed
    Summary
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    This study found that propranolol plasma levels above 20 ng/ml significantly block beta-adrenergic receptors. Doses around 160 mg daily achieve this, reducing exercise heart rate effectively in normal men.

    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology

    Background:

    • Propranolol is a beta-blocker used in various cardiovascular conditions.
    • Understanding optimal dosing for therapeutic effect is crucial.

    Purpose of the Study:

    • To determine the relationship between propranolol dosage, plasma levels, and beta-blockade in healthy individuals.
    • To establish effective propranolol plasma concentrations for achieving beta-blockade.

    Main Methods:

    • 169 healthy men received varying propranolol doses and placebo.
    • Plasma propranolol levels and reduction in exercise tachycardia were measured.
    • Dose-response and frequency-response relationships were analyzed.

    Main Results:

    • Plasma propranolol levels exceeding 20 ng/ml induced significant beta-blockade.

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  • A daily dose slightly over 160 mg achieved minimum plasma levels above 20 ng/ml.
  • Approximately 50% of subjects experienced a 20 bpm decrease in exercise tachycardia at 160 mg/day.

    • Conclusions:

    • Beta-blockade degree correlates with propranolol dose, not frequency.
    • Effective beta-blockade is achieved with plasma levels >20 ng/ml.
    • Findings align with observations from large clinical trials of propranolol.