Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium nephrotoxicity

P J Perry

    Drug Intelligence & Clinical Pharmacy
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Lithium therapy can cause kidney damage (nephrotoxicity) in humans, even without intoxication. Factors like dosing and formulation influence this risk.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An 11-year retrospective review of venlafaxine ingestion in children from the California Poison Control System.

    Human & experimental toxicology·2015
    Same author

    Increased risk of extrapyramidal side-effect treatment associated with atypical antipsychotic polytherapy.

    Acta psychiatrica Scandinavica·2006
    Same author

    Therapeutic drug monitoring of antipsychotics.

    Psychopharmacology bulletin·2002
    Same author

    DNA tetraplex-binding drugs: structure-selective targeting is critical for antitumour telomerase inhibition.

    Mini reviews in medicinal chemistry·2002
    Same author

    The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1.

    British journal of cancer·2002
    Same author

    Bupropion SR vs. methylphenidate vs. placebo for attention deficit hyperactivity disorder in adults.

    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists·2002
    Same journal

    Profile of prescription medication in a pediatric population.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    SI units in drug therapeutics.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    Physicians' review of significant interventions by clinical pharmacists in inpatient care.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    Possible interaction of ranitidine with phenytoin.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    Famotidine-associated mental confusion in elderly patients.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    Intravenous self-administration of elemental mercury: efficacy of dimercaprol therapy.

    Drug intelligence & clinical pharmacy·1988
    See all related articles

    Area of Science:

    • Nephrology
    • Pharmacology
    • Psychiatry

    Background:

    • Lithium-induced nephrotoxicity was predicted in animals over 30 years ago.
    • Human evidence emerged in the 1970s, indicating renal damage from chronic lithium therapy.
    • Lithium intoxication is not always required for nephrotoxicity to develop.

    Purpose of the Study:

    • To review the evidence and identified risk factors for lithium-induced nephrotoxicity in humans.
    • To understand the relationship between lithium treatment and renal damage.

    Main Methods:

    • Review of accumulated evidence and anecdotal information regarding lithium's effects on the kidneys.
    • Identification of factors influencing nephrotoxicity risk.

    Main Results:

    Related Experiment Videos

    • Renal damage can occur with chronic lithium therapy, not solely during acute intoxication.
    • Several factors influence the risk of developing lithium-induced nephrotoxicity.

    Conclusions:

    • Chronic lithium therapy poses a risk of nephrotoxicity.
    • Factors such as the number of daily doses, lithium formulation, and pre-existing renal disease in patients with bipolar disorder can influence this risk.